중등도 치주질환에 대한 Vitamin C, Vitamin E, lysozyme, carbazochrome (이가탄®) 복합제제의 임상 효과
Clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) in periodontal disease : Double blind, randomized control study
장윤영, 김창성, 정의원, 최성호, 김백일, 엄유정, 정임희, 장용주,
소속 상세정보
장윤영 ( Chang Yun-Young ) - 연세대학교 치과대학 치주과학교실
김창성 ( Kim Chang-Sung ) - 연세대학교 치과대학 치주과학교실
정의원 ( Jung Ui-Won ) - 연세대학교 치과대학 치주과학교실
최성호 ( Choi Seong-Ho ) - 연세대학교 치과대학 치주과학교실
김백일 ( Kim Baek-Il ) - 연세대학교 치과대학 예방치과학교실
엄유정 ( Um Yoo-Jung ) - 연세대학교 치과대학 치주과학교실
정임희 ( Jung Im-Hee ) - 연세대학교 치과대학 치주과학교실
장용주 ( Jang Yong-Ju ) - 연세대학교 치과대학 치주과학교실
KMID : 0362720090470120830
Abstract
Purpose : The purpose of this study was to evaluate the clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) for periodontal disease
Material and Methods : The study was performed by double blinded, ramdomized method. Forty two subjects diagnosed as chronic incipient or moderate periodontitis at department of periodontology, Yonsei Dental Hospital were included in the study. This study was approved by Institutional Review Board , Yonsei Universtiy Hospital.
All subjects received scaling at their first examination and second examination was scheduled after 2 weeks. At second
examination, periodontal parameters such as plaque index(PI), gingival index(GI), probing depth(PD), bleeding on probing(BOP), gingival recession(GR) and clinical attachment level(CAL) were recorded(Baseline) with prescription of Vitamin C, Vitamin E, lysozyme, carbazochrome complex(IGATAN®) (Experimental group 23 subjects) or placebo medicine(Control group; 19 subjects). The subjects were recalled after 4 weeks for periodontal parameters measurement.
Results : In the experimental groups, PI, GI, CAL and BOP scores were significantly reduced at 4 weeks compared to baseline. A statistically significant decrease in GI and BOP scores were observed in the experimental group compared to the control group.
Conclusion : It can be concluded that Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) have an effect in reducing gingival bleeding and improving periodontal inflammatory condition inchronic incipient- moderate periodontitis.
키워드
Vitamin C; Vitamin E; lysozyme; carbazochrome
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